Gaspari Plasma Jet

After almost 2 years in development, the most intense and effective nitric oxide boosting product ever seen or sold in the sports supplement industry... and we mean EVER, is here. We knew the last thing this industry needed was another "me too" NO product, but when you come across something so unique and so powerful that its bound to obliterate an entire category, what choice did we have. This is not just about instant gratification…its about big gains - now and down the road. Sure PlasmaJet™ will increase definition and vascularity, but also size, strength and endurance on a level previously unattainable by ANY other nitric oxide mediated sports supplement EVER! Finally, a Nitric Oxide product that will really take your physique to new heights... and not just for a few fleeting hours or a few days. Forget your previous experience or preconceived notions about what NO products can or can't do. You'll be amazed at what PlasmaJet™ will do for you!

• Massive Muscle Pumps
• Increases Gains in Lean Muscle Mass, Strength and Stamina
• Increased Vascularity
• Stimulates Glycogen Building in Skeletal Muscle
• Maximum Vasodilation
• Increased Uptake of Amino Acids and Other Nutrients
• Post Cycle Therapy Powerhouse

1st Key Point: It's not so much 'how' but 'when' that is important & critical Most Arginine-type NO supplements suggest you take them everyday.

The easiest solution to resolving the Arginine/NO tolerance issue is NOT TO TAKE ARGININE in large amounts everyday. We decided, that after testing PlasmaJet™ on some "big guns" along the Jersey Shore that you should never mega-dose on Arginine more that 3-4X per week and it best taken just prior or during workouts. This allows for maximal stimulation of the NO system and peak vasodilation - it means more nutrients and O2 gets to muscle, letting you do the extra reps, and it means more garbage/waste products get ferreted away, including CO2, so the muscles cells can start recovering immediately with no delay. So even if you don't want to try PlasmaJet™ you can still use the other companies Arginine/NO products - just don't use them everyday, only use them on 3-4X per week before you hit the gym. See, I'm being pretty forthright here, even if you elect to use the "other guy's NO product" I just saved you 50% in the cost of your supplement and surely helped to optimize your results from said product.

2nd Key Point: Are there any supplements that can extend the effects of Arginine or the needed co-factors (NADH and NOS) to maximize the time of vasodilation? In a word - YES! There are plenty and some of them are dirt cheap. Let's look at what things we can throw into the mix to make Arginine work longer and better, along with NADH and NOS. These are the "prime movers" of PlasmaJet™ - it has other, secondary and critical ingredients but for the sake of brevity, I can't discuss each and everyone, just those that are absolutely of most importance to the product.

VITAMIN C
Vitamin C (J Cardiovasc Pharmacol. 2002 Dec;40(6):890-7.) greatly enhances NOS activity by increasing something called intracellular tetrahydrobiopterin. This is a very inexpensive and highly efficacious way to extend the effects of arginine/NO based vasodilation and I am stunned that no other company before Gaspari Nutrition opted to add sufficiently effective amounts of Vitamin C to their Arginine based, NO mediated supplements. For literally pennies (Vitamin C is very inexpensive) a company can make any Arginine based NO supplement from 29%-85%+ more effective at preventing decrease of vascular tone and attenuation. Yes you read that correctly, up to 85% more effective just by adding a good dose of Vitamin C. Vitamin C seems to have a tangible, beneficial effect on NO bioavailability induced by Arginine too (Heart. 2005 Oct;91(10):1319-23.). So it's really stupid not to have substantial amounts of Vitamin C with any Arginine based product!

QUERCETIN/RED WINE EXTRACTS
The flavanoid quercetin (relatively inexpensive and easily available) dramatically increases NOS activity/production so it needs to be in any NO product (J Hypertens. 2006 Jan;24(1):75-84.) because it would make any supplement that relies on an NO mediated system more effective. So why don't we see all these Arginine and NO products loaded with quercetin then like PlasmaJet™ contains? Additionally, red wine extract/polyphenols (FASEB J. 2005 Mar;19(3):455-7.) demonstrably increases the synthesis of NOS (which is needed to make more NO!) via the redox-sensitive activation of the PI3-kinase/Akt pathway in the vascular endothelial cells which, in turn, causes phosphorylation of NOS, resulting in an increased formation of NO.

NADH
To have an effective NO mediated product you just can't have Arginine! You need to increase the amounts of NOS to make NO from Arginine as well as NADH and other co-factors or else no matter how much Arginine... any type of Arginine... you consume, it in will end up "petering out" when you run out of NOS, NADH, etc., in the vascular endothelium! There is no way around it! That's just a fact of life! How much NADH do the other guys have in their NO product? Do they have any at all? If not why not, the stuff is readily available. PlasmaJet™ has a whopper dose of this vital co-factor of NO production in the formula.

ICARIIN
The herb "Horny Goat Weed" (Epimedium sagittatum) has been used as a male aphrodisiac in Chinese herbal medicine for hundreds of years. It's been somewhat effective in this role most likely because of a single flavanoid contained in the herb called Icariin. This is another "why didn't the other guys think to put this into their NO mediated supplement" type of chemical. Icariin seems to actually work at genetically causing an increased capacity for the production of NO (Acta Pharmacol Sin. 2006 Mar;27(3):311-20). Additionally, when pure (98%) Icariin was given orally to several test groups of rats (Asian J Androl. 2005 Dec;7(4):381-8) it also caused a significant increase in the amount of NOS as well as increasing the percent of smooth muscle found in the corpus cavernosum (penis) of the rats. So this stuff seems to be a winner from many angles - it works at increasing both NO and NOS and it increases the amount of muscle found in the blood vessel... can you say bigger, harder erections? If you can't, you can certainly say 'bigger, harder muscles" because an increase in vascular smooth muscle percentage, which is something Icariin causes, means potential increases in the dilation capacity of a blood vessel - this would make Icariin a critical ingredient to any NO mediated supplement in my opinion. Gaspari's new PlasmaJet™ contains one of the purest Icariin currently sold today and is much more potent than the commercial Horny Goat Weed which is found in our supplement market place today (Horny Goat Weed typically contains up to 1-%10% Icariin by weight).

GYPENOSIDE
There is another Chinese herb (Jiaogulan which is also known as the "immortality herb" containing Gypenoside) that should also be in any NO mediated supplement to radically increase the efficacy of the product. In a study done in 1999 at Vanderbilt University Medical Center and the Department of Veterans Affairs Hospital, Nashville, Tennessee, Gypenoside extracted from Gynostemma pentaphyllum was tested in a clinical study (Nitric Oxide. 1999 Oct;3(5):359-65); the study clearly demonstrated Gypenoside caused vasorelaxation/dilation through the direct release of endothelium-derived nitric oxide. Nitric oxide production in bovine aortic endothelial cells grown under standard tissue culture conditions was quantitated using a chemiluminescence method. The scientists tested the effect of Gypenoside and found that this causes a dose dependent vasorelaxation/dilation WHICH WAS REVERSIBLE by the nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester. These results demonstrate that Gypenoside directly stimulates nitric oxide release from cells. The Gaspari product uses the pure chemical (gypenoside) and not the herbal extract or dried herb.

ADENOSINE 5'-TRIPHOSPHATE
The next critical ingredient found in PlasmaJet™ and I might add, found exclusively in PlasmaJet™ (in an NO formula that is) is something really cool. Adenosine 5'-TriPhosphate [(ATP) is the ONLY energy source that the human body can truly utilize, irrespective of aerobic or anaerobic activity. Go on, read the sentence again, you know you want to! ATP is responsible for virtually all (100%) of metabolic processes in living organisms. It is responsible for regulating every physiological activity through its interactions with receptors. But in addition to being the base fuel source for human life, ATP also has some very interesting, if not unique NO/vasodilatory properties too. Because Gaspari Nutrition has the utmost respect for intellectual property rights/patents, we have engaged Dr. Eliot Rapaport of Harvard University fame/TSI. Dr. Rapaport has spent more than 30 years studying the physiological actions of ATP and is the recognized expert on adenosine nucleotides. He currently holds EIGHT issued patents regarding ATP use with many more pending. Gaspari Nutrition has successfully agreed to license ATP (more specifically, in the form of the disodium salt, NA2ATP - tradename is PeakATP®) from Dr. Rapaport/TSI for use in an NO type product (PlasmaJet™). So what will the unique, added PeakATP® found exclusively in PlasmaJet™ mean to you regarding NO/vasodilation?

ATP has been demonstrated to increase vasodilation by stimulating endogenous NO synthesis in STRIATED MUSCLE (the kind of muscle found in your biceps and deltoids for example). ATP has been shown to enhance the delivery of oxygen, glucose and other nutrients to WORKING SKELETAL MUSCLES (those biceps and shoulders again!). ATP "works" at "giving you a massive pump" by increasing NO synthesis, NO independent prostacyclin dilation (PG12) and NO independent EDHF synthesis among other things. A small increase in blood ATP levels can cause an 8% increase in blood vessel diameter and a 17% increase in blood flow. That might not sound like a lot but if you have say…18" arms or so, an 8% increase in the diameter of your arms would mean your arms would measure around better than 21" (remember ?r2 from math class now?)!!! Sound substantial yet?!? Let's review the various mechanisms that ATP can increase "pump" as well as some other ways it will lead to bigger, fuller muscles above and beyond the NO mechanisms (this is like getting a "freebie" or "extra bonuses" here)?!?

• ATP stimulates glycogen building in skeletal muscle via GLUT4 insulin transport.
• o ATP increases vasodilation via the ATP degenerated product adenosine as a vasodilator.
• ATP increases oxygen flow and L-Arginine uptake through GLUT4 insulin transport which increases the uptake of amino acids and other nutrients.
• ATP synergizes with CoQ10, an electron transport carrier, during the process of respiration and oxidative phosphorylation, increasing bioavailability with an increase of O2 flow.

ATP does all this (and more) with absolutely no adverse effect on heart rate or blood pressure, it is not a stimulant and in clinical research studies (studies done on real living people and not in a Petri dish somewhere) NO SIDE EFFECTS WERE OBSERVED IN TWO RANDOMIZED CLINICAL TRIALS (WITH 319 HUMAN TEST SUBJECTS) IN OVER 30 DAYS OF TREATMENT! For more information about the safety and efficacy of ATP (specifically the PeakATP® that Gaspari Nutrition licenses for use in our NO product PlasmaJet™) please see MED SCI SPTS EXERC. 2004;983-990 - J RHEUMATOLOGY 2005; JUN;32(6):1114-1117 - PHARMACOEPIDEMIOL DRUG SAF 2005; DEC; 14(12): 861-867

Remember, Gaspari Nutrition's new PlasmaJet™ NO product is the only company using ATP in an NO product due to our license with the patent holder, Dr. Eliot Rapaport/TSI. You can only get ATP in an NO product by using PlasmaJet™ and I would imagine, due to its obvious effectiveness in helping to build muscle fast and its apparent high margin of safety when compared to other ingredients in other products, you're going to want to use the PeakATP® for sure.

In conclusion, there can be NO DOUBTS as to the usefulness of Arginine/NO for bodybuilders or any other resistance training athletes, especially those that have dabbled in hormonal augmentation (legal or otherwise). Arginine mediated NO synthesis will stop working in a matter of days and the usefulness of Arginine is dubious if it is used on a daily basis. We suggest using an Arginine product no more than every other day at a maximum. Additionally, there are several co-factors needed to insure a maximal vasodilatory response to Arginine that many products on the market do not incorporate into their formulas. This problem has been corrected with Gaspari Nutrition's PlasmaJet™ NO stimulating product. Why did we call it PlasmaJet™? Because in the world of chemistry and physics, "plasma" is the highest, most excited state of matter. The "hottest" thing. Run one PlasmaJet™ Kit (or one oral dose for that matter!) and see what a true scientific approach to NO can do.