The New Standard for natural Optimized Male Hormonal Performance What Do Men Want? Optimal Performance, Of Course! Okay, by now everyone in the industry knows that the male body actually can produce way more testosterone than it needs. Like as much as 400% increase above what is normal for you, and maintain it for months at a time, naturally? Is this some lame claim of “steroid-like” effects from a legal supplement? Nope! Just some advance science applied for the betterment of men everywhere. Of course there are several excellent and innovative supplement companies around. We just like being one of them. Yup, Anabolic Xtreme. is pissing off all of the industry talkers and copiers again. This time we did it with a whole new approach to a now over copied idea: Natural Optimized Male Human Performance through the optimization of male human physiology. No, this is not just some silly-ass sex product either. And no it is not simple ATD and 3-OHAT. We simply updated and left others to catch up...because we can. First, Let’s Make Sure Everyone Is On the Same Page A man’s body produces almost all of its limited supply of natural testosterone by way of the HPTA (Hypothalamus-Pituitary-Testes-Axis). Basically, the Hypothalamus and the Pituitary tell the testes just how much testosterone to make...or not. It also decides your performance level more than you think. Multipule factors called negative feedback loops regulate HPTA activity and limit the amount of testosterone you have: Estrogen Negative Feedback loop In males, testosterone is converted into estrogen by an enzyme called aromatase. Normally, higher levels of testosterone also mean excess estrogen. The hypothalamus “senses” the excess estrogen and limits or shuts down testosterone production. Estrogen increases fat stores as well. Thanks to our modern environment, plastics and soy-everything, we already have far too much unnatural estrogens to deal with. Androgen Negative Feedback loop The hypothalamus also senses increases in testosterone. This is mediated through androgen receptors. An increase in testosterone also results in the hypothalamus telling the testes to limit or shut down testosterone production. But estrogen gets to run amok doing girlie things to your body anyway. So the key to increase testosterone production naturally and significantly (to a point that really matters) is controlling these multipule negative feedback loops (not just one). How? Step 1: Estrogen Negative Feedback Loop Modulation 6-acetoxy-3-hydroxy-17-keto-etioallocholane is a new powerful systemic anti-aromatase that decreases estrogen levels in males an average of 50% everywhere in the body... including in and around the hypothalamus. And it is effective in a one time daily administration. 17a-methyl-17b-hydroxyl-3-keto-delta 1,4,6-etioallocholtriene: is another new and highly effective aromatase inhibiting compound. The reason is rather simple in that it binds to aromatase more tightly than any other available product due to a unique high affinity. Yes, it is an interesting analog of ATD. However there is a far more important reason that we employed this highly unique compound: Peripheral inhibition including neuro-tissues. But we will get to that in a minute. More science stuff first. So now we have two compounds that synergistically rid our male bodies of excess estrogen. But what about the Androgen Negative Feedback Loop? Step 2: Destroy the Androgen Negative Feed Back Loop...Before It Occurs. 17a-methyl-17b-hydroxyl-3-keto-delta 1,4,6-etioallocholtriene is also most likely the most powerful site-specific (like the hypothalamus) androgen receptor agonist. Based upon some animal studies the unique structure of this compound allows for an 80-90% reduction in androgen receptor activity of the hypothalamus, yet only a very small decrease in the rest of the body. So all of that extra testosterone you are now making really works in all the right places! Of course, someone with a limited knowledge of physiological Action/Reaction Factors will claim some lame idea that this means testosterone is blocked from doing all of its cool things where it matters too. In case anyone missed the point, it is a site-specific androgen receptor agonist that modulates the Androgen Negative Feed-Back Loop. So, would you rather have an average increase in testosterone production of 400% with a little 10% potential reduction in activity or be average? Gee, tough choice... not. Remember I said that there is a far more important reason that we employed second highly unique compound? Peripheral inhibition including neuro-tissues. 1) What many do not seem to be aware of is the fact that within both the systemic Estrogen Negative Feedback loop and the Androgen Negative Feedback loop is another pathway that acts to inhibit maximized hormonal performance. Simply put, when neuro-tissue androgen and estrogen receptors are over stimulated there is a signal sent to the HPTA that tells it “stop making lots of natural testosterone”. 2) The second issue is that when systemic (whole body) estrogen levels get Too low, there is too dramatic of a rebound effect post use. This means that after we stop using the product the body thinks that there is a severe need to make lots of estrogen and it does so from all of that nice free testosterone. When we cut systemic estrogen levels into the acceptable lower ranges (about 50% normal) THEN inhibit periphrial tissue aromatization SITE SPECIFICALLY, the result is less rebound and more testosterone. Estrogen “Clearing” Is a Must Too Agaricus bisporus extract is a very interesting item that finishes this manly matrix to maximize results. Oddly enough it is an extract of a specific white button mushroom from a specific area that has been shown in research studies to act upon the aromatase enzyme on multiple levels making this the perfect “mop” to excrete any remaining excess estrogen from a mans body. Just Because It Is Interesting... Avena Sativa is well known for its capacity to increase libido through increased levels of free testosterone. In theory this is due to positive control of the proteins SHBG and Albumin that bound and inactivate testosterone. Seems the reports from users of quality extracts of avena sativa are pretty favorable. Unfortunately we have not been able to find a single quality study to support these anecdotal reports you can find in mass all over the internet. Hmmm, maybe this does “help” to explain the improved free to total testosterone profiles observed those whom have used PCT™. PCT™ is a patent pending proprietary matrix for men that is guaranteed to: • Support Natural Testosterone • Modulate Fat Causing Estrogens • Decrease Water Retention • Support Libido & Performance • Improve recovery References: Horm Behav. 1989 Mar;23(1):10-26. Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis Biol Reprod. 2003 Feb;68(2):370-4. Estrogen synthesis in fetal sheep brain: effect of maternal treatment with an aromatase inhibitor. J.Steroid Biochem. 1987 Sep;28(3):337-44 Studies on aromatase inhibition with 4-androstene-3.6.17-trione: Its 3-beta reduction and time dependant irreversible binding to aromatase with human placental microsomes J Nutr. 2001 Dec;131(12):3288-93. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. Grube BJ, Eng ET, Kao YC, Kwon A, Chen S. J Steroid Biochem. 1986 Oct;25(4):593-600. Effect of 1,4,6-androstatriene-3,17-dione (ATD), 4-hydroxy-4-androstene-3,17-dione (4-OH-A) and 4-acetoxy-4-androstene-3,17-dione (4-Ac-A) on the 5 alpha-reduction of androgens in the rat prostate J Steroid Biochem Mol Biol. 1992 Oct;43(4):281-7. In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the brain Gen Comp Endocrinol. 1999 Sep;115(3):442-53. Combined aromatase inhibitor and antiandrogen treatment decreases territorial aggression in a wild songbird during the nonbreeding season. Steroid control and sexual differentiation of brain aromatase. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):323-39. Review. Brain Res. 1995 Dec 1;701(1-2):267-78. Pre- and post-translational regulation of aromatase by steroidal and non-steroidal aromatase inhibitors. Prenatal inhibition of aromatase activity affects luteinizing hormone feedback mechanisms and reproductive behaviors of adult guinea pigs. Biol Reprod. 1994 Dec;51(6):1273-8. Organizational effects of testosterone via aromatization on feminine reproductive behavior and neural progestin receptors in rat brain. Endocrinology. 1984 Oct;115(4):1412-7.