Simply put, creatine monohydrate is the most popular, effective and proven bodybuilding supplement on the market. Most athletes consistently using creatine are gaining in strength, muscle and are enhancing their performance. Excellent results have been observed in taking creatine monohydrate in two different ways. The first way is called loading, which works very well for anyone who has never taken creatine before. Just as the name implies, it involves loading up or saturating your muscles with creatine.