Gaba is the neurotransmitter to growth hormone output. Growth hormone has been shown to increase stem cell proliferation, reduce oxidative damage to the kidneys, increase insulin sensitivity, and promote greater androgen output.
Gaba is an inhibitory neurotransmitter, which means it slows down brain function whilst increasing potential for anabolism (or the increase of tissue density). The problem with gaba, however, is that its molecular structure is too large to bypass the blood-brain barrier. As such, supplemental form has been thought to be useless.
Yet the brain does have a region called the periventricular nucleus which can be reached by direct gaba intake. The periventricular nucleus is an area of the hypothalamus that regulates leptin, ghrelin and potential growth hormone release. Through the direct intake of gaba we increase the output of growth hormone through stimulation of the periventricular nucleus.
This is interesting because the combination of dopamine-inducing amino acids with gaba could offer an increased neural edge as well as increase the overall output or reaction of growth.